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CMF

There are three drugs in this regimen, Cytoxan,  Methotrexate and 5-FU , all of which are given intravenously.

Dosage administration schedule is as follows:

Cytoxan

600 Mg per M2

Day # 1

Methotrexate

40 Mg per M2

Day # 1

5-FU

600 Mg per M2

Day # 1

All three drugs are administered in one session and the cycle is repeated in three to four weeks, as soon as patient recovers for the side effects.

Variant of CMF

Cytoxan

100 Mg per M2* PO*

Days # 1 to 14

Methotrexate

40 Mg per M2

Days # 1and 8

5-FU

600 Mg per M2

Days # 1 and 8

M2 is body surface area which is the square footage of a patient's body surface. This is measured based on height and weight of the patient.

PO is taking a medicine orally, taking a tablet.

The most significant side effects of these regimes are:

Menstrual Changes