Colon cancer is another very common form of cancer in this country and genetic factors seem to play a role in up to 10% of cases.  First degree relatives of all patients with this cancer should be monitored carefully.  This cancer has a tendency to run in families and be associated with genetic abnormalities, for which they can be tested for.  Family members should have close follow ups and be seen by a physician.  Family members, depending on their risk level, may need to have certain tests and colonoscopy done on a regular schedule.  Individuals who test positive should be under close surveillance, starting at an early age and consider surgery.

Abnormalities in certain genes such as APC, MLH1, MSH2, PMS1 and PMS2 genes are considered to be associated with a higher risk of developing colon cancer.  Presence of these abnormal genes can increase the risk of other cancers, such as endometrial and ovarian cancers.
 

Cancer Genetic issues