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Tamoxifen (Nolvadex)

Tamoxifen is one of the older hormone-manipulating agents and has been in use for over two decades.  This drug is potent Estrogen Receptor Manipulator and is used in treatment of Hormone sensitive tumors such as Breast cancer in both early stages of the disease as an adjuvant treatment and in patients with metastatic disease.   Tamoxifen comes in 10 and 20 mg tablets and the normal daily dose is one tablet twice daily.  Some patients tolerate a dose of   20 mg at bed time much better.

Recent studies have shown that Tamoxifen can prevent breast cancer development in high risk women.

Side effects:

This drug is rather well tolerated and has minimal side effects, among which are:

• Hot Flashes

• Fluid retention

• Vaginal Discharge

• Irregular menses

• Tendency to form blood clots

Some of these side effects improve over time.  It is imperative that patients relay any side effects or problems to their medical oncologists.